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18F-DOPA PET/CT Scans for Brain Cancer

Phase 2
Waitlist Available
Led By Derek R. Johnson, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 and older
Diagnosis of a brain tumor
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 days post-pet scan, up to 64 days
Awards & highlights
No Placebo-Only Group

Summary

"This trial aims to see if adding a special imaging test called 18F-DOPA PET/CT to the standard imaging tests can help better manage brain tumors in more than 50% of cases

Who is the study for?
This trial is for adults with a brain tumor who need advanced imaging, like before surgery or to check if treatment is working. It's not for those unable to undergo PET scans or pregnant/nursing individuals.
What is being tested?
The study tests whether adding an investigational scan called 18F-DOPA PET/CT can improve the management of brain tumors when combined with standard imaging techniques over half the time.
What are the potential side effects?
Since this trial involves diagnostic scans rather than medication, side effects are minimal but may include discomfort from lying still during the scan and exposure to a small amount of radiation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
Select...
I have been diagnosed with a brain tumor.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 days post-pet scan, up to 64 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 days post-pet scan, up to 64 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Impact of 18F-DOPA PET/CT on clinical management
Secondary study objectives
Incidence of adverse events
Rate of identification of tumor outside of standard magnetic resonance imaging (MRI)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Diagnostic (18F-DOPA)Experimental Treatment3 Interventions
Patients receive 18F-DOPA IV and undergo PET/CT over 30 minutes on day 1.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fluorodopa F 18
2019
Completed Phase 2
~50
Computed Tomography
2017
Completed Phase 2
~2740
Positron Emission Tomography
2011
Completed Phase 2
~2200

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,337 Previous Clinical Trials
3,061,127 Total Patients Enrolled
Derek R. Johnson, MDPrincipal InvestigatorMayo Clinic in Rochester
~31 spots leftby Oct 2029
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