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Caspase-1 Inhibitor

Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19

Phase 2
Waitlist Available
Led By Glenn Wortmann, MD
Research Sponsored by MedStar Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up days 4, 7, 10, 14, 21, 28, 42, and 60 post randomization

Summary

This trial tests a pill called Belnacasan for patients with mild to moderate COVID-19. The pill aims to reduce harmful inflammation by blocking an enzyme that can cause the immune system to overreact and damage organs.

Eligible Conditions
  • Coronavirus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~days 4, 7, 10, 14, 21, 28, 42, and 60 post randomization
This trial's timeline: 3 weeks for screening, Varies for treatment, and days 4, 7, 10, 14, 21, 28, 42, and 60 post randomization for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Safety and Tolerability of Belnacasan
Secondary study objectives
Caspase-1
Changes on the WHO 9-Point Ordinal Scale
Experiences of COVID-19 Related Deterioration and Mortality
+17 more

Side effects data

From 2022 Phase 2 trial • 40 Patients • NCT05164120
10%
Chest pain
100%
80%
60%
40%
20%
0%
Study treatment Arm
Interventional
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: InterventionalExperimental Treatment1 Intervention
900mg dose TID Administration Total: 2700mg
Group II: PlaceboPlacebo Group1 Intervention
0 mg dose TID Administration Total: 0 mg
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Belnacasan
2021
Completed Phase 2
~40

Find a Location

Who is running the clinical trial?

MedStar HealthLead Sponsor
4 Previous Clinical Trials
70,398 Total Patients Enrolled
Glenn Wortmann, MDPrincipal InvestigatorMedStar Health
1 Previous Clinical Trials
414 Total Patients Enrolled
~10 spots leftby Dec 2025
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