Probiotics for Long COVID
(PURE-LC Trial)

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Rush University Medical Center

Prior Safety Data

Trial Summary

What is the purpose of this trial?The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID. The main questions it aims to answer are: 1. Do probiotics reduce the number and severity of symptoms in those with Long COVID? 2. Do probiotics improve physical and mental health quality of life in those with Long COVID? 3. Do probiotics improve return to work and daily activities in those with Long COVID? Researchers will compare probiotics to a placebo (a look-alike substance that contains no probiotics) to see if probiotics works to treat Long COVID. Participants will take the study medication (placebo or probiotic) for 4 months. They will then cross-over (take the other medication) for an additional 4 months. Participants will complete a survey at baseline, 4 months, and 8 months.

Eligibility Criteria

This trial is for individuals experiencing lingering symptoms after COVID-19, known as Long COVID. Participants should have ongoing issues but no current infection. The study excludes those with immune system disorders, on certain medications, or who are pregnant.

Inclusion Criteria

I am over 18 and have long-lasting symptoms from COVID.

Exclusion Criteria

I do not have symptoms of Long COVID anymore.

Are unable to take the study medication daily

Are currently pregnant or planning to become pregnant over the course of the study

+4 more

Participant Groups

The study tests if probiotics can alleviate Long COVID symptoms and improve life quality compared to a placebo. It's a crossover trial where participants switch between the probiotic and placebo every four months and report their progress.

2Treatment groups

Active Control

Placebo Group

Group I: Probiotic ArmActive Control1 Intervention

Probiotic pill taken once daily

Group II: Placebo ArmPlacebo Group1 Intervention

Identical placebo pill taken once daily