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Anti-caries agent

Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

Phase 2
Waitlist Available
Led By Travis Nelson, DDS
Research Sponsored by Advantage Silver Dental Arrest, LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 21 days
Awards & highlights
No Placebo-Only Group

Summary

This trial studies how well a cavity-fighting medicine works in children, and looks at its effects in the body over time.

Who is the study for?
This trial is for healthy children aged 13 months to 13 years who live close to the study site and have at least one untreated cavity. Kids with mouth sores, allergies to silver or fluoride, or recent SDF treatments can't join.
What is being tested?
The study tests how a tooth decay treatment called Advantage Arrest (38% silver diamine fluoride) behaves in kids' bodies. After treating cavities, researchers will check blood levels of the drug at different times.
What are the potential side effects?
Possible side effects may include temporary staining of teeth or skin where applied, mild irritation around the treated area, and very rarely an allergic reaction due to sensitivity to silver or fluoride.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~21 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 21 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Area Under Curve, Fluoride
Area Under Curve, Silver
Fluoride Cmax
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Silver diamine fluorideExperimental Treatment1 Intervention
Silver diamine fluoride, 38%, topical, single application
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
38% silver diamine fluoride
2017
Completed Phase 2
~40

Find a Location

Who is running the clinical trial?

University of WashingtonOTHER
1,826 Previous Clinical Trials
1,906,026 Total Patients Enrolled
Advantage Silver Dental Arrest, LLCLead Sponsor
5 Previous Clinical Trials
600 Total Patients Enrolled
Travis Nelson, DDSPrincipal InvestigatorUniversity of Washington
~8 spots leftby Dec 2025
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