Your session is about to expire
← Back to Search
NMDA Receptor Antagonist
KAP for Depression in Abstinent Opioid Users (KReDO Trial)
Phase 2
Waitlist Available
Led By Eric T Dobson, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing if ketamine shots combined with talking therapy can help people with past opioid addiction who are now depressed. Ketamine quickly changes brain activity to improve mood, while therapy helps manage emotions. Ketamine is used in treating multiple pain, mental health, and substance abuse disorders due to its rapid-acting pain relief and mood improvement effects.
Eligible Conditions
- Depression
- Addiction
- Recovered from addiction
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Montgomery Asberg Depression Rating Scale
Secondary study objectives
Beck Depression Inventory
Brief Pain Inventory (BPI)
Generalized Anxiety Disorder-7 (GAD-7)
+4 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Ketamine-assisted psychotherapyExperimental Treatment1 Intervention
Subjects will receive 8 weekly intramuscular injections of ketamine hydrochloride starting at 0.5 mg/kg and increasing to a maximum dose of 1.5 mg/kg or a total dose of 60 mg, whichever is lower. Ketamine administration will be accompanied by psychotherapy before, after and during the session.
Find a Location
Who is running the clinical trial?
Medical University of South CarolinaLead Sponsor
979 Previous Clinical Trials
7,400,989 Total Patients Enrolled
44 Trials studying Depression
7,338 Patients Enrolled for Depression
Eric T Dobson, MDPrincipal InvestigatorMedical University of South Carolina