Urea in Dialysis Fluid for Renal Disease

Recruiting in Palo Alto (17 mi)

Overseen ByRamin Sam, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: University of California, San Francisco

No Placebo Group

Trial Summary

What is the purpose of this trial?At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and/or fix the metabolic acidosis.

Eligibility Criteria

This trial is for patients with advanced kidney failure who have dangerously high levels of potassium or severe acidosis, and very high blood urea nitrogen (BUN) levels. It's not suitable for those who might experience a rapid drop in BUN leading to disequilibrium syndrome.

Inclusion Criteria

I require dialysis.

Serum Urea > 120

My blood potassium is high, or my CO2 levels are low, or I need dialysis due to poisoning.

Exclusion Criteria

I am under 18 years old.

I require continuous renal replacement therapy.

Participant Groups

The study tests adding urea to the dialysis fluid. This could help manage serum BUN levels while aggressively treating high potassium or acidosis without risking disequilibrium syndrome during dialysis.

1Treatment groups

Experimental Treatment

Group I: Urea dialysateExperimental Treatment1 Intervention

Patients who had urea added to the final dialysis fluid