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Glucagon-like peptide-1 receptor agonist

Single-arm: Semaglutide for HIV (SLIM LIVER Trial)

Phase 2
Waitlist Available
Research Sponsored by AIDS Clinical Trials Group
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from pre-entry to week 24
Awards & highlights
No Placebo-Only Group

Summary

This trial will assess if a diabetes drug (Ozempic®) can reduce body fat and protect against heart & diabetes in HIV+ people. MRI will measure body fat.

Eligible Conditions
  • Prediabetes
  • HIV
  • Obesity
  • Fatty Liver
  • Insulin Resistance

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from pre-entry to week 24
This trial's timeline: 3 weeks for screening, Varies for treatment, and from pre-entry to week 24 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change (absolute) in intra-hepatic triglyceride (IHTG) (%)

Side effects data

From 2020 Phase 4 trial • 104 Patients • NCT04189848
21%
Nausea
12%
Decreased Appetite
100%
80%
60%
40%
20%
0%
Study treatment Arm
Overall Study

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Single-arm: SemaglutideExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Semaglutide
2021
Completed Phase 4
~5160

Find a Location

Who is running the clinical trial?

AIDS Clinical Trials GroupLead Sponsor
100 Previous Clinical Trials
73,572 Total Patients Enrolled
National Institute of Allergy and Infectious Diseases (NIAID)NIH
3,313 Previous Clinical Trials
5,547,628 Total Patients Enrolled
Kristine Erlandson, MD, MSStudy ChairUniversity of Colorado Hospital CRS
1 Previous Clinical Trials
51 Total Patients Enrolled
~13 spots leftby Oct 2025
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