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SOC heart failure therapy with addition of metolazone (Arm B) for Heart Failure (MELT-HF Trial)

Phase 2
Waitlist Available
Led By James T Heywood, MD
Research Sponsored by Scripps Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6, 12, 24, 36, and 48 hours

Summary

The primary objective of the study is to determine efficacy of metolazone as synergistic therapy with Lasix in patients with acute decompensated heart failure. This will be a multicenter double blinded randomized placebo- controlled pilot study of the addition of 5 mg of metolazone per day for 2 days compared to placebo in patients admitted with acute decompensated heart failure.

Eligible Conditions
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6, 12, 24, 36, and 48 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6, 12, 24, 36, and 48 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Total urinary output and negative fluid balance
Secondary study objectives
All cause mortality
Change in weight
Degree of improvement in dyspnea

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: SOC heart failure therapy with addition of metolazone (Arm B)Active Control1 Intervention
This group will receive all standard heart failure therapy with addition of metolazone.
Group II: SOC heart failure therapy and placebo pill (Arm A)Placebo Group1 Intervention
This group will receive all standard heart failure therapy and placebo pill.

Find a Location

Who is running the clinical trial?

Scripps HealthLead Sponsor
58 Previous Clinical Trials
43,573 Total Patients Enrolled
4 Trials studying Heart Failure
517 Patients Enrolled for Heart Failure
James T Heywood, MDPrincipal InvestigatorScripps Health
2 Previous Clinical Trials
108 Total Patients Enrolled
2 Trials studying Heart Failure
108 Patients Enrolled for Heart Failure
~0 spots leftby Oct 2025
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