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Opioid Analgesic

Problems With Morphine Use in Patients With a Severe Brain Injury

Phase 1 & 2
Waitlist Available
Led By Richard I Hall, MD
Research Sponsored by Dalhousie University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Approved for 5 Other Conditions
No Placebo-Only Group

Summary

Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood brain barrier. This loss results in the penetration into the brain of certain drugs that are normally excluded by the transporter protein. In this study the working hypothesis is that the agitation observed in patients with CNS trauma treated with morphine is related to the inflammation evoked loss of PGP in the blood brain barrier and the accumulation of the morphine metabolite 3-morphine glucuronide.

Eligible Conditions
  • Subarachnoid Hemorrhage
  • Head Trauma
  • Head Injuries

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Active Control
Group I: 0Active Control1 Intervention

Find a Location

Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,392 Previous Clinical Trials
26,529,425 Total Patients Enrolled
1 Trials studying Subarachnoid Hemorrhage
742 Patients Enrolled for Subarachnoid Hemorrhage
Dalhousie UniversityLead Sponsor
173 Previous Clinical Trials
401,834 Total Patients Enrolled
Richard I Hall, MDPrincipal InvestigatorCapital Health- QE II HSC
1 Previous Clinical Trials
35 Total Patients Enrolled
~1 spots leftby Dec 2025
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