Metal Detoxification for Acute Myeloid Leukemia

Recruiting in Palo Alto (17 mi)

Overseen byMaro Ohanian, DO

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

The goal of this clinical research study is to learn if metal detoxification (with calcium disodium edetate \[Ca-EDTA\] and dimercaptosuccinic acid \[DMSA\]) during standard therapy can help improve outcomes in patients with intermediate-risk, high-risk, or secondary AML compared to standard therapy alone. Researchers think lowering the level of metals found in the blood/bone marrow may help to control the disease and/or improve the response to chemotherapy.

Research Team

Maro Ohanian, DO

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for individuals with intermediate-risk, high-risk, or secondary Acute Myeloid Leukemia (AML). Participants should be undergoing standard therapy for AML. Specific inclusion and exclusion criteria details are not provided but would typically relate to health status and prior treatments.

Inclusion Criteria

My cancer outside the bone marrow can be tracked for treatment response.

I have signed or will sign a consent form (or my legal representative has if I'm unable).

I am 18 years old or older.

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Exclusion Criteria

I have been treated with venetoclax, but it did not work for me.

I do not have any severe illnesses or social situations that would stop me from following the study's requirements.

I have been diagnosed with Acute Promyelocytic Leukemia.

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Treatment Details

Interventions

Ca-EDTA (Chelating Agent)
DMSA (Chelating Agent)

Trial OverviewThe study tests if using metal detoxification agents like Ca-EDTA and DMSA during standard AML therapy can improve patient outcomes. It's a phase 2 randomized study where some patients will receive these additional treatments while others will not.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Metal Detoxification with DMSA + Ca-EDTA with Standard AML TherapyExperimental Treatment4 Interventions

Participants treatment will be administered on either an inpatient or outpatient basis