Probiotics and Gut Health
(PRO Trial)

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Recruiting

Sponsor: Penn State University

Trial Summary

What is the purpose of this trial?This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a break in between. These periods will occur in random order.

Eligibility Criteria

Inclusion Criteria

BMI ≥ to 25 and less than 35 kg/m^2

serum triglycerides: ≥ 150 mg/dL

HDL cholesterol: ≤ 40 mg/dL in men, ≤ 50 mg/dL in women

+4 more

Participant Groups

2Treatment groups

Experimental Treatment

Placebo Group

Group I: ExperimentalExperimental Treatment1 Intervention

Participants will consume one yogurt smoothie daily for the duration of the intervention that contains 3.16 × 109 colony forming units (CFU) bifidobacterium animalis subsp. lactis BB-12. Participants will be asked to refrain from consumption of other yogurt or probiotic-containing foods.

Group II: ControlPlacebo Group1 Intervention

Participants will consume one yogurt smoothie daily for the duration of the intervention that contains no BB-12. Participants will be asked to refrain from consumption of other yogurt or probiotic-containing foods.