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Androgen

Effect of Testosterone Treatment on Embryo Quality

Phase 1 & 2
Waitlist Available
Led By David H Barad, MD, MS
Research Sponsored by Center for Human Reproduction
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks post treatment initiation
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions

Summary

This trial will compare the effects of testosterone cream to placebo on measures of ovarian reserve, oocyte quality, embryo quality, and pregnancy rates in women with diminished ovarian reserve who have low serum testosterone and free testosterone levels after completing six weeks of DHEA supplementation.

Eligible Conditions
  • Premature Ovarian Failure
  • Diminished Ovarian Reserve
  • Primary Ovarian Insufficiency

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks post treatment initiation
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks post treatment initiation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Clinical and Ongoing Pregnancy
Secondary study objectives
Measures of Atresia
Oocytes number

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: DHEA+TestosteroneActive Control2 Interventions
These patients will be administered the testosterone cream along with standard DHEA supplements
Group II: DHEA+PlaceboPlacebo Group2 Interventions
These patients will receive the placebo cream along with her DHEA supplements. In other words, no testosterone will be administered.

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor
13 Previous Clinical Trials
987 Total Patients Enrolled
Foundation for Reproductive MedicineOTHER
3 Previous Clinical Trials
149 Total Patients Enrolled
David H Barad, MD, MSPrincipal InvestigatorCenter for Human Reproduction
4 Previous Clinical Trials
505 Total Patients Enrolled
Norbert Gleicher, MDStudy ChairCenter for Human Reproduction
8 Previous Clinical Trials
645 Total Patients Enrolled
~13 spots leftby Dec 2025
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