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Alpha-1 Blocker

Tamsulosin for Urinary Retention (PrePOURTS Trial)

Phase 2
Recruiting
Led By Rahul Nayal
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male Sex
Age greater than or equal to 40 years
Must not have
Active treatment of Benign Prostatic Hyperplasia (BPH)
Active urinary tract infection
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months

Summary

This trial aims to see if tamsulosin is better than a placebo in helping reduce urinary retention and improving outcomes in people having lung surgery.

Who is the study for?
This trial is for men aged 40 or older who have had urinary retention before, a prostate symptom score of at least 1, diabetes, and are using thoracic epidural analgesia. They can't join if they're allergic to tamsulosin, recently took alpha-blockers, have a UTI or BPH being treated, neurological bladder issues, past urological surgery or disorders like strictures or cancer.
What is being tested?
The study tests whether Tamsulosin Hydrochloride can prevent urinary retention after lung surgery compared to a placebo. Participants will be randomly assigned to receive either the medication or an inactive substance.
What are the potential side effects?
Tamsulosin may cause dizziness, headache, sleepiness, nausea, runny nose and ejaculation problems. It might also lead to low blood pressure when standing up which could make someone faint.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am male.
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I am 40 years old or older.
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I have been diagnosed with diabetes.
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I have had radiation therapy to my pelvic area before.
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I am using a thoracic epidural for pain management.
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I have had issues with not being able to empty my bladder fully in the past.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am currently being treated for an enlarged prostate.
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I currently have a urinary tract infection.
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I have a history of specific urinary problems or cancer.
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I have had surgery on my bladder or prostate.
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I have a nerve condition that affects my bladder control.
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I have no known allergies or adverse reactions to tamsulosin HCL.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Enrollment Effectiveness
Monthly recruitment
Protocol adherence
Secondary study objectives
Catheter related complications
Length of stay
Rate of Indwelling Catheterizations
+3 more

Side effects data

From 2018 Phase 4 trial • 715 Patients • NCT02757768
2%
Headache
2%
Hypertension
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Mirabegron

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: TreatmentExperimental Treatment1 Intervention
Tamsulosin
Group II: PlaceboPlacebo Group1 Intervention
Placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tamsulosin Hydrochloride
2018
Completed Phase 4
~1240

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
680 Previous Clinical Trials
421,402 Total Patients Enrolled
Rahul NayalPrincipal InvestigatorLawson Health Research Institute
~40 spots leftby Dec 2025
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