EEG Monitoring for Anesthesia in Aging

Recruiting in Palo Alto (17 mi)

Overseen byPatrick L. Purdon, PhD

Age: 65+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?In this study, we propose to evaluate the relationship between the alpha oscillation dynamics and the signals derived from the brain images related to brain aging.

Eligibility Criteria

This trial is for people aged 65 or older who are fluent in English and scheduled for surgery under general anesthesia. They must be generally healthy (ASA I-III) with no cognitive impairment, dementia, severe obesity, MRI contraindications like metal implants, or a history of significant neurological or psychiatric conditions.

Inclusion Criteria

I am scheduled for surgery under general anesthesia.

My overall health is good to moderately impaired.

I am 65 years old or older.

+2 more

Exclusion Criteria

I have a history of serious brain or psychiatric conditions.

Language impairment

My BMI is 40 or higher.

+6 more

Participant Groups

The study is looking at how brain wave patterns during anesthesia (alpha oscillation dynamics) relate to brain images and aging. Participants will have their EEG monitored during surgery to see if these signals can predict changes in the brain associated with getting older.

2Treatment groups

Active Control

Group I: Treatment GroupActive Control1 Intervention

Anesthesiologists in the treatment group use the unprocessed EEG waveforms and EEG spectrogram to maintain appropriate levels of unconsciousness for general anesthesia while avoiding burst suppression.

Group II: Control GroupActive Control1 Intervention

Anesthesiologists managing patients assigned to the control group will manage each anesthetic based on their clinical judgment, using standard monitoring required by American Society of Anesthesiologists (ASA), which include cardiac and respiratory monitoring, but not EEG monitoring.