Low-Intensity Focused Ultrasound for Clinical Follow-up

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Virginia Polytechnic Institute and State University

No Placebo Group

Trial Summary

What is the purpose of this trial?This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.

Eligibility Criteria

This trial is for English-speaking individuals willing to use a medication monitoring system. It's not suitable for those with pacemakers, metal implants, history of significant head injury or substance dependence, active CNS-affecting medical conditions, pregnancy, or claustrophobia.

Inclusion Criteria

Patients must be willing to use a Pillsy medication event monitoring system

Must understand and speak English

I can speak and read English.

+1 more

Exclusion Criteria

History of alcohol or drug dependence

Presence of pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants

I have had a head injury that made me unconscious for more than 10 minutes.

+5 more

Participant Groups

The study tests how different durations of Low-Intensity Focused Ultrasound (LIFU) affect muscle contractions. Participants will undergo brain imaging and stimulation techniques while their muscle responses are recorded.

1Treatment groups

Experimental Treatment

Group I: Duration TrialsExperimental Treatment1 Intervention

Six different durations (three intermittent and three continuous) of LIFU application will be tested across six study sessions. Response recorded using TMS and EMG.