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Choline for Cardiovascular Risk

N/A
Waitlist Available
Led By Kevin Davy, PhD
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* 18-65 years old, healthy, non-smoking weight stable for previous 6 months (±2.0 kg), BMI\<35 kg/m\^2, verbal and written informed consent, approved for participation by study medical director (Jose Rivero, M.D.)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 45-minute measurement in laboratory

Summary

This trial is studying how well trimethylamine-N-oxide (TMAO) works in improving vascular function in people with stable cardiovascular disease.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~45-minute measurement in laboratory
This trial's timeline: 3 weeks for screening, Varies for treatment, and 45-minute measurement in laboratory for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in brachial artery function after supplementation
Secondary study objectives
Change in arterial stiffness after supplementation
Change in gut-mediated TMAO levels after supplementation

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Short Term Choline SupplementationExperimental Treatment1 Intervention
Participants will be asked to consume 1000 mg of choline bitartrate for 4 weeks prior to and during the testing period.
Group II: Short Term Placebo SupplementationPlacebo Group1 Intervention
Participants will be asked to consume 1000 mg of placebo (maltodextrin) for 4 weeks prior to and during the testing period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Choline
2018
Completed Phase 4
~620

Find a Location

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
153 Previous Clinical Trials
25,063 Total Patients Enrolled
3 Trials studying Cardiovascular Risk
56 Patients Enrolled for Cardiovascular Risk
Kevin Davy, PhDPrincipal Investigator - Virginia Polytechnic Institute and State University
Virginia Polytechnic Institute and State University
4 Previous Clinical Trials
98 Total Patients Enrolled
3 Trials studying Cardiovascular Risk
56 Patients Enrolled for Cardiovascular Risk
~3 spots leftby Nov 2025