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Chemotherapy

A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer (PROTACT Trial)

Phase 2
Waitlist Available
Led By Talia Golan, MD
Research Sponsored by Silenseed Ltd
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Approved for 10 Other Conditions
No Placebo-Only Group

Summary

This trial uses a small device that releases a drug directly into pancreatic tumors, targeting patients who can't have surgery. The device is used with standard treatment to see if it improves the response. Bazedoxifene is being tested to see if it works well with the standard treatment for pancreatic cancer.

Eligible Conditions
  • Pancreatic Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: siG12D-LODER + chemotherapyExperimental Treatment3 Interventions
Eight siG12D-LODER+Gemcitabine+nab-Paclitaxel or Eight siG12D-LODER+Folfirinox or Eight siG12D-LODER+modifide Folfirinox
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Folfirinox
2018
Completed Phase 3
~760

Find a Location

Who is running the clinical trial?

Silenseed LtdLead Sponsor
1 Previous Clinical Trials
15 Total Patients Enrolled
Talia Golan, MDPrincipal InvestigatorSheba Medical Center
1 Previous Clinical Trials
24 Total Patients Enrolled
Eileen M O'Reilly, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
1 Previous Clinical Trials
217 Total Patients Enrolled
~10 spots leftby Dec 2025
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