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Mucolytic Agent

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Phase 2
Waitlist Available
Led By Gerard M Turino, MD
Research Sponsored by Gerard Turino
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights
All Individual Drugs Already Approved

Summary

The purpose of the study is to evaluate the safety and efficacy of administering repeated doses of Hyaluronic Acid Inhalation Solution to subjects with Emphysema that have Alpha-1-Antitrypsin deficiency

Eligible Conditions
  • Alpha-1 Antitrypsin Deficiency
  • CPFE Syndrome
  • Emphysema

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Assessment of pulmonary function tests
Measurement of sputum, plasma and urine concentrations of desmosine and isodesmosine
Secondary study objectives
Assessment of St. George Respiratory Questionnaire

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Hyaluronic Acid inhalation solutionExperimental Treatment1 Intervention
3mL of 0.03% Hyaluronic Acid inhalation solution BID for 28 days
Group II: Placebo Inhalation SolutionPlacebo Group1 Intervention
3mL matching placebo inhalation solution BID for 28 days
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hyaluronic acid
FDA approved

Find a Location

Who is running the clinical trial?

Gerard TurinoLead Sponsor
Gerard M Turino, MDPrincipal InvestigatorMount Sinai St Lukes
~3 spots leftby Dec 2025
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