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PET/CT for Alzheimer's Disease (ABCD2-TAU Trial)

N/A
Recruiting
Led By David A Wolk, MD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 years
Awards & highlights
No Placebo-Only Group

Summary

This trial uses a special brain scan to look at tau proteins in older adults who currently show no signs of cognitive problems. The goal is to understand early brain changes that might lead to Alzheimer's disease. This imaging method has been developed to noninvasively detect tau protein deposits in the brain, which are associated with neurodegeneration and cognitive impairment in Alzheimer's disease.

Eligible Conditions
  • Alzheimer's Disease
  • Dementia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Temporal Lobe
Uptake of [18F]AV-1451 in the medial temporal lobe
Volume of medial temporal lobe subregion

Side effects data

From 2022 Phase 2 trial • 125 Patients • NCT04080544
7%
Elevated blood pressure
1%
Black dot in visual field
1%
Muscle soreness in injection arm
1%
Neck rash
1%
Diarrhea, drowsiness, nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Follow up DLBS Participants

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: PET/CTExperimental Treatment1 Intervention
PET.CT using the radiotracer \[18F\]AV-1451
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
[18F]AV-1451
2019
Completed Phase 2
~130

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,076 Previous Clinical Trials
42,719,665 Total Patients Enrolled
Pennsylvania Department of HealthOTHER_GOV
41 Previous Clinical Trials
998,235 Total Patients Enrolled
David A Wolk, MDPrincipal InvestigatorUniversity of Pennsylvania
1 Previous Clinical Trials
102 Total Patients Enrolled
~79 spots leftby May 2027
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