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A Study of Two Doses of MRC375 in Moderate to Severe Rheumatoid Arthritis Patients

Phase 2
Waitlist Available
Research Sponsored by Molecular Research Center, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 weeks

Summary

This trial tests MRC375, a pill taken regularly, in adults with moderate to severe rheumatoid arthritis. The medication might help reduce joint inflammation and pain by using an ingredient that can also fight bacteria.

Eligible Conditions
  • Rheumatoid Arthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Efficacy evaluated of both doses of MRC375 compared to placebo after 24 weeks of treatment as measured by the rate of achievement of 20% improvement in ACR criteria
Secondary study objectives
Compare the Efficacy of two doses of MRC375 when compared to a placebo for the change from baseline screening in each of the individual ACR components measuring RA after 24 weeks of treatment
Safety and tolerability of both doses of MRC375

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: MRC375 75 mgExperimental Treatment1 Intervention
MRC375 (enteric coated Tetracycline) 75 mg 3 times a day
Group II: MRC375 150mgExperimental Treatment1 Intervention
MRC375 (enteric coated Tetracycline) 150mg 3 times a day for 24 weeks.
Group III: PlaceboPlacebo Group1 Intervention
Placebo

Find a Location

Who is running the clinical trial?

Bilcare Global Clinical SuppliesUNKNOWN
Harrison Clinical ResearchIndustry Sponsor
5 Previous Clinical Trials
1,104 Total Patients Enrolled
BARC Global Central LaboratoryUNKNOWN
Molecular Research Center, Inc.Lead Sponsor
Camargo Pharmaceutical ServicesIndustry Sponsor
2 Previous Clinical Trials
26 Total Patients Enrolled
Clin Data ServicesUNKNOWN
~21 spots leftby Dec 2025
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