Oral Methadone for Post-Surgery Pain

Phase 3

Waitlist Available

Led By Alexander Chen, M.D.

Research Sponsored by Keck School of Medicine of USC

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at post-anesthesia care unit arrival, post-operative 30 minutes, post-op 60 minutes, post-operative day 1, and post-operative day 2

Awards & highlights

Pivotal Trial

Summary

This trial aims to determine if giving oral methadone before surgery can help reduce post-operative pain and the need for opioid pain medications. Participants will either receive oral methadone or a placebo before surgery

Who is the study for?

This trial is for individuals scheduled for knee surgery or hip arthroscopy. Participants must meet certain health requirements, which are not specified here. People who do not meet these health standards or have conditions that could interfere with the study's outcomes will be excluded.

What is being tested?

The trial is testing if taking oral methadone before surgery can reduce pain and the need for opioids after surgery compared to a placebo (a substance with no drug). Patients will either receive methadone or a placebo and track their pain and opioid use post-surgery.

What are the potential side effects?

While specific side effects are not listed, common side effects of methadone may include nausea, drowsiness, constipation, lightheadedness, and potential risk of addiction or withdrawal symptoms.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at post-anesthesia care unit arrival, post-operative 30 minutes, post-op 60 minutes, post-operative day 1, and post-operative day 2

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at post-anesthesia care unit arrival, post-operative 30 minutes, post-op 60 minutes, post-operative day 1, and post-operative day 2

This trial's timeline: 3 weeks for screening, Varies for treatment, and at post-anesthesia care unit arrival, post-operative 30 minutes, post-op 60 minutes, post-operative day 1, and post-operative day 2 for reporting.