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Kinase Inhibitor

Lapatinib and RAD-001 for Breast Cancer

Phase 2
Waitlist Available
Led By Qamar Khan, MD
Research Sponsored by University of Kansas Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

By doing this study, researchers hope to learn the effectiveness of the combination of Lapatinib and RAD-001 for treating patients who have progressed on previous therapies.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Assess the effectiveness of the combination of RAD-001 and lapatinib
Secondary outcome measures
Overall benefit of combination

Trial Design

1Treatment groups
Experimental Treatment
Group I: Lapatinib and RAD-001Experimental Treatment1 Intervention
RAD-001 will be administered orally as a once-daily dose of 5 mg (one 5 mg tablet) continuously from study day 1 until progression of disease or unacceptable toxicity. Patients will be instructed to take RAD-001 in the morning, at the same time each day. Lapatinib will be administered orally as a once-daily dose of 1250 mg (five 250 mg tablets) continuously from study day 1 until progression of disease or unacceptable toxicity. Patients will be instructed to take lapatinib at bedtime, at the same time each day. Lapatinib should be taken by the patient in a fasting state.

Find a Location

Who is running the clinical trial?

University of Kansas Medical CenterLead Sponsor
470 Previous Clinical Trials
171,399 Total Patients Enrolled
23 Trials studying Breast Cancer
4,510 Patients Enrolled for Breast Cancer
NovartisIndustry Sponsor
1,614 Previous Clinical Trials
2,721,329 Total Patients Enrolled
57 Trials studying Breast Cancer
21,179 Patients Enrolled for Breast Cancer
GlaxoSmithKlineIndustry Sponsor
4,768 Previous Clinical Trials
8,105,714 Total Patients Enrolled
32 Trials studying Breast Cancer
2,326,304 Patients Enrolled for Breast Cancer
~2 spots leftby May 2025
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