Creatine in Treating Patients With Cancer-Associated Weight Loss

Recruiting in Palo Alto (17 mi)

+219 other locations

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 3

Waitlist Available

Sponsor: Alliance for Clinical Trials in Oncology

Pivotal Trial (Near Approval)

Prior Safety Data

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?

RATIONALE: It is not yet known whether the supplement creatine is effective in increasing weight and improving appetite and quality of life in patients who have cancer. PURPOSE: This randomized phase III trial is studying how well creatine works in increasing weight and improving appetite and quality of life in patients with weight loss caused by cancer.

Eligibility Criteria

Inclusion Criteria

Considered incurable with available therapies

Histologically or cytologically confirmed cancer other than primary brain cancer

History of weight loss ≥ 5 lbs in 2 months or fewer AND/OR estimated intake of < 20 cal/kg daily

Treatment Details

Interventions

• Creatine (Dietary Supplement)
• Placebo (Other)

Participant Groups

Group I: Arm I Experimental Treatment 1 Intervention

Patients receive oral creatine daily.

Group II: Arm II Placebo Group 1 Intervention

Patients receive oral placebo daily.

Creatine is already approved in United States, European Union for the following indications:

🇺🇸 Approved in United States as Creatine Monohydrate for:

• Dietary supplement for muscle growth and performance
• Potential treatment for post-concussive symptoms

🇪🇺 Approved in European Union as Creatine Monohydrate for:

• Dietary supplement for muscle growth and performance
• Potential treatment for post-concussive symptoms

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Swedish Medical Center Englewood, CO

Van Elslander Cancer Center at St. John Hospital and Medical Center Grosse Pointe Woods, MI

CCOP - Colorado Cancer Research Program Denver, CO

St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center Grand Junction, CO

More Trial Locations

Who Is Running the Clinical Trial?

Alliance for Clinical Trials in Oncology Lead Sponsor

National Cancer Institute (NCI) Collaborator

References