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Anti-tumor antibiotic
Study of Relacorilant in Combination With Nab-Paclitaxel for Patients With Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Madrid, Spain
Phase 2
Waitlist Available
Research Sponsored by Corcept Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months from enrollment of last subject
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing a new drug called relacorilant with another drug in patients whose ovarian, fallopian tube, or peritoneal cancer does not respond to standard treatments. Relacorilant may help make the treatment more effective by targeting specific parts of the body. The other drug has been widely used and studied for its effectiveness in treating various cancers, including ovarian cancer.
See full description
Eligible Conditions
- Ovarian Cancer
- Peritoneal Carcinoma
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months from enrollment of last subject
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months from enrollment of last subject
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Progression Free Survival (PFS)
Secondary study objectives
Best Overall Response (BoR)
Best Overall Response in patients who crossover to continuous treatment at time of PD
Cancer Antigen (CA)-125 Response
+9 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Intermittent Relacorilant DosingExperimental Treatment2 Interventions
Patients will be treated with relacorilant, administered orally, on the day before (excluding Cycle 1, Day -1), the day of, and the day after nab-paclitaxel, in combination with nab-paclitaxel on Days 1, 8, and 15 of each 28-day cycle.
Group II: Continuous Relacorilant DosingExperimental Treatment2 Interventions
Patients will be treated with relacorilant, administered orally, once daily every day in combination with nab-paclitaxel on Days 1, 8, and 15 of each 28-day cycle.
Group III: Nab-paclitaxel ComparatorActive Control1 Intervention
Patients will receive nab-paclitaxel on Days 1, 8, and 15 of each 28-day cycle.
Find a Location
Closest Location:Site Reference ID/Investigator #127· Pittsburgh, PA· 163 miles
Who is running the clinical trial?
Corcept TherapeuticsLead Sponsor
70 Previous Clinical Trials
6,415 Total Patients Enrolled
Dorothy Nguyen, MDStudy DirectorCorcept Therapeutics
5 Previous Clinical Trials
395 Total Patients Enrolled
Lyndah Dreiling, MDStudy DirectorCorcept Therapeutics
5 Previous Clinical Trials
755 Total Patients Enrolled