Pembrolizumab + Gemcitabine for Bladder Cancer
Trial Summary
The trial protocol does not specify if you need to stop taking your current medications. However, you must not have received certain treatments like systemic anti-cancer therapy or radiotherapy within specific timeframes before joining the trial. It's best to discuss your current medications with the trial team.
Pembrolizumab has been shown to improve survival in patients with advanced urothelial cancer and is approved for use in certain types of bladder cancer. Gemcitabine is commonly used in combination with other drugs for bladder cancer treatment, suggesting potential effectiveness when combined with Pembrolizumab.
12345Pembrolizumab and Gemcitabine have been studied for safety in various conditions, including bladder cancer. Gemcitabine was well tolerated in studies with few side effects, and Pembrolizumab has been approved by the FDA for certain types of bladder cancer, indicating a recognized safety profile.
12346Pembrolizumab + Gemcitabine is unique because it combines an immune checkpoint inhibitor (Pembrolizumab) with chemotherapy (Gemcitabine), offering a novel approach for patients who cannot tolerate traditional cisplatin-based treatments. This combination leverages the immune system to fight cancer while also using chemotherapy to target cancer cells directly.
12345Eligibility Criteria
This trial is for adults with high-grade non-muscle invasive bladder cancer that hasn't responded to BCG treatment. Candidates must have had all visible tumors removed, not be pregnant or breastfeeding, agree to birth control use, and have proper organ function. Those unfit for radical cystectomy or refusing it can join. People with certain infections, recent radiation therapy to the lungs, active autoimmune diseases, other cancers within three years, or previous treatments with similar drugs are excluded.Inclusion Criteria
Exclusion Criteria
Participant Groups
- Non-small cell lung cancer
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
- Pancreatic cancer
- Non-small cell lung cancer
- Breast cancer
- Ovarian cancer
- Pancreatic cancer
- Non-small cell lung cancer
- Breast cancer
- Ovarian cancer
- Pancreatic cancer
- Non-small cell lung cancer
- Breast cancer
- Ovarian cancer