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Diuretic

Acetazolamide for the Prevention of Post Operative CSF Leak

Phase 2
Waitlist Available
Led By Ronald Benveniste, MD, PhD
Research Sponsored by University of Miami
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights
No Placebo-Only Group

Summary

This trial will test if using Acetazolamide can prevent cerebrospinal fluid leaks in patients post-operatively.

Eligible Conditions
  • Cerebrospinal Fluid Drainage
  • Cerebrospinal Fluid Leak

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of CSF Leakage
Secondary study objectives
Incidence of suspected drug events

Side effects data

From 2022 Phase 4 trial • 11 Patients • NCT03377049
9%
External Ventricular Drainage infection
9%
Hydrocephalus
9%
Pulmonary edema
9%
Cardiomyopathy
100%
80%
60%
40%
20%
0%
Study treatment Arm
Acetazolamide Challenge

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Acetazolamide ArmExperimental Treatment1 Intervention
Participants in this arm will receive the Acetazolamide intervention for 7 consecutive days post standard of care endoscopic skull base surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetazolamide
2011
Completed Phase 4
~3030

Find a Location

Who is running the clinical trial?

University of MiamiLead Sponsor
950 Previous Clinical Trials
428,393 Total Patients Enrolled
Ronald Benveniste, MD, PhDPrincipal Investigator - University of Miami
Univ of Miami Hosp & Clinics-Sylvester Comp Cancer Center, University of Miami Hospital
Washington University School Of Medicine (Medical School)
Mt Sinai School Of Medicine (Residency)
2 Previous Clinical Trials
12 Total Patients Enrolled
~0 spots leftby Dec 2025
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