Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

Recruiting in Palo Alto (17 mi)

+168 other locations

Overseen by Michelle C Janelsins

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: University of Rochester NCORP Research Base

Prior Safety Data

Approved in 7 Jurisdictions

Trial Summary

What is the purpose of this trial?

This randomized phase II trial studies how well low-dose ibuprofen in improving cognitive impairment in patients with cancer. Anti-inflammatory agents, such as ibuprofen, may slow the decline of cognitive processes and diseases involving the brain.

Eligibility Criteria

Inclusion Criteria

Have a diagnosis of cancer and have had surgery and are now receiving adjuvant or neoadjuvant chemotherapy or who have received chemotherapy within the last 6 months; chemotherapy with concurrent radiation therapy (RT) is allowed

Answer YES to the question: "Have you noticed any problems in your memory, attention, concentration, multi-tasking or other cognitive functions?" any time after initiation of chemotherapy cycle 1

NOTE: If a participant answers NO, they may be re-approached at a subsequent cycle

Treatment Details

Interventions

• Ibuprofen (Nonsteroidal Anti-inflammatory Drug)

Participant Groups

Group I: Arm I (ibuprofen) Experimental Treatment 2 Interventions

Patients receive ibuprofen PO BID for 6 weeks.

Group II: Arm II (placebo) Placebo Group 2 Interventions

Patients receive placebo PO BID for 6 weeks.

Ibuprofen is already approved in United States, Canada, European Union, Australia, Japan, China, Switzerland for the following indications:

🇺🇸 Approved in United States as Advil for:

• Pain relief
• Fever reduction
• Inflammation

🇨🇦 Approved in Canada as Motrin for:

• Pain relief
• Fever reduction
• Inflammation

🇪🇺 Approved in European Union as Nurofen for:

• Pain relief
• Fever reduction
• Inflammation

🇦🇺 Approved in Australia as Ibuprofen for:

• Pain relief
• Fever reduction
• Inflammation

🇯🇵 Approved in Japan as Ibuprofen for:

• Pain relief
• Fever reduction
• Inflammation

🇨🇳 Approved in China as Ibuprofen for:

• Pain relief
• Fever reduction
• Inflammation

🇨🇭 Approved in Switzerland as Ibuprofen for:

• Pain relief
• Fever reduction
• Inflammation

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Illinois CancerCare-Bloomington Bloomington, IL

Marie Yeager Cancer Center Saint Joseph, MI

Munson Medical Center Traverse City, MI

Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, NV

More Trial Locations

Who Is Running the Clinical Trial?

University of Rochester NCORP Research Base Lead Sponsor

National Cancer Institute (NCI) Collaborator

References