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Senolytic Drug

Fisetin for Coronavirus

Phase 2
Waitlist Available
Led By James L Kirkland, MD, PhD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test whether Fisetin can help prevent the progression of coronavirus and its complications.

Who is the study for?
Adults aged 18+ with COVID-19 confirmed by a PCR test, especially those over 60 or aged 18-59 with conditions like obesity, diabetes, lung diseases (asthma/COPD), heart issues (past strokes or heart attacks), high blood pressure, history of smoking/vaping, or past chemotherapy/radiation. Must not be pregnant and willing to use contraception.Check my eligibility
What is being tested?
The trial is testing Fisetin—a drug that might reduce inflammation and prevent worsening of coronavirus symptoms—against a placebo. Participants will randomly receive either Fisetin or an inactive substance to compare outcomes.See study design
What are the potential side effects?
Specific side effects for Fisetin are not detailed here but may include typical drug reactions such as allergic responses, gastrointestinal discomforts, headaches, dizziness or other common medication-related side effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in oxygenation status
Serious Adverse Events
Secondary outcome measures
CoV Severity Category

Side effects data

From 2022 Phase 2 trial • 55 Patients • NCT04771611
7%
Rash
7%
hyperhidrosis
7%
Chest pain
7%
Diarrhea
7%
Sinusitis
7%
Infectious Rash
7%
Back Pain
7%
Headache
7%
Worsening Headache
7%
Dyspnea
7%
sore throat
3%
hypertension
3%
tachycardia
3%
amnesia
3%
asthma with exacerbation
3%
Anosmia
3%
migraine
3%
conjunctivitis
3%
rhinitis
3%
flu like symptoms
3%
Otitis media
3%
vertigo
3%
edema, hand, bilateral
3%
bacterial vaginosis
3%
ear pain, left
3%
cough
3%
Upper Respiratory Infection
3%
Epistaxis
3%
flatulence
3%
shortness of breath
3%
arthoplasty
3%
ageusia
3%
change in smell
3%
vomiting
3%
fatigue
3%
Colic Renal
3%
Nephrolithiasis Calcium Oxalate
3%
sneezing
3%
thrush
3%
right shoulder arthroscopy, rotator cuff, repair
3%
watering eyes (epiphora)
3%
Systolic murmur
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment Group
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment GroupExperimental Treatment1 Intervention
Subjects will receive treatment drug Fisetin
Group II: Placebo GroupPlacebo Group1 Intervention
Subjects will receive placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fisetin
2016
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,242 Previous Clinical Trials
3,773,669 Total Patients Enrolled
James L Kirkland, MD, PhDPrincipal InvestigatorMayo Clinic
4 Previous Clinical Trials
155 Total Patients Enrolled
~8 spots leftby Dec 2024
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