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Behavioral Intervention

Genetic Counseling and Lifestyle Change for Diabetes Prevention (GC/LC Trial)

Phase 2
Waitlist Available
Led By Richard W Grant, MD MPH
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years

Summary

This study will examine the impact diabetes genetic counseling on patient motivation and disease prevention behaviors among subjects with pre-diabetes. Intervention subjects will be provided with their individual diabetes genotype risk score derived from aggregating the combined results of 37 diabetes risk-associated genetic loci. Controls will not be tested. All subjects will be enrolled in a 12-week diabetes prevention program.

Eligible Conditions
  • Metabolic Syndrome
  • Prediabetes
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Diabetes Genetic CounselingExperimental Treatment1 Intervention
Subjects will have been genotyped and will received genetic counseling based on their results
Group II: No Genotyping or CounselingPlacebo Group1 Intervention
Patients will not be genotyped and will therefore not receive genetic counseling

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
3,026 Previous Clinical Trials
13,413,709 Total Patients Enrolled
14 Trials studying Metabolic Syndrome
891 Patients Enrolled for Metabolic Syndrome
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,464 Previous Clinical Trials
4,337,363 Total Patients Enrolled
35 Trials studying Metabolic Syndrome
2,850 Patients Enrolled for Metabolic Syndrome
Richard W Grant, MD MPHPrincipal InvestigatorMassachusetts General Hospital
6 Previous Clinical Trials
2,953 Total Patients Enrolled
~6 spots leftby Dec 2025
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