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PI3Kγ inhibitor

IPI-549 for Head and Neck Squamous Cell Carcinoma

Phase 2
Recruiting
Led By Ezra Cohen, MD
Research Sponsored by Ezra Cohen
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will investigate whether IPI-549 is an effective treatment against cancer.

Eligible Conditions
  • Head and Neck Cancers
  • Cervical Cancer
  • Head and Neck Squamous Cell Carcinoma
  • Squamous Cell Carcinoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
PI3K-y changes
Secondary study objectives
Changes of Myeloid composition
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
changes in T cell composition

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Arm A: IPI-549 40 mg PO qdailyExperimental Treatment1 Intervention
Patients enrolled in Arm A will receive IPI-549 40 mg by mouth daily for at least 14 days
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
IPI-549
2018
Completed Phase 1
~40

Find a Location

Who is running the clinical trial?

The V Foundation for Cancer ResearchOTHER
20 Previous Clinical Trials
1,293 Total Patients Enrolled
Ezra CohenLead Sponsor
4 Previous Clinical Trials
58 Total Patients Enrolled
Ezra Cohen, MD4.8134 ReviewsPrincipal Investigator - University of California, San Diego
13 Previous Clinical Trials
748 Total Patients Enrolled
4Patient Review
Dr Raush was very amiable and gentle. This was my first visit to an optometrist in years, but they were able to take care of everything I needed — including my DMV form. I had a lovely time.
~3 spots leftby Nov 2025
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