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Loop Diuretic

Furosemide for Heart Failure (TRANSFORM-HF Trial)

Phase 3
Waitlist Available
Led By Eric Velazquez, MD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 months
Awards & highlights

Summary

This trial will compare the effects of two different diuretics on heart failure patients.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
All-cause mortality, as measured by follow-up phone call
Secondary outcome measures
All-cause mortality or all-cause hospitalization, as measured by follow-up phone call
Health-related quality of life, as measured by follow-up phone call
Symptoms of depression, as measured by follow-up phone call
+1 more

Trial Design

2Treatment groups
Active Control
Group I: FurosemideActive Control1 Intervention
Oral dosing of torsemide compared to furosemide will be 1mg:2-4mg. For patients receiving loop diuretics other than furosemide, conversion to furosemide equivalents will be as follows: 1 mg oral torsemide = 2-4 mg oral furosemide 1 mg oral or intravenous bumetanide = 40 mg oral furosemide
Group II: TorsemideActive Control1 Intervention
Oral dosing of torsemide compared to furosemide will be 1mg:2-4mg.

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,889 Previous Clinical Trials
47,831,348 Total Patients Enrolled
208 Trials studying Heart Failure
674,850 Patients Enrolled for Heart Failure
Yale UniversityOTHER
1,907 Previous Clinical Trials
3,016,190 Total Patients Enrolled
34 Trials studying Heart Failure
55,350 Patients Enrolled for Heart Failure
Duke UniversityLead Sponsor
2,424 Previous Clinical Trials
3,063,225 Total Patients Enrolled
63 Trials studying Heart Failure
43,658 Patients Enrolled for Heart Failure
~399 spots leftby Sep 2025
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