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Immunomodulator

Alpha interferon (aIFN) treatment for Lymphoma

Phase 2
Waitlist Available
Research Sponsored by Children's Oncology Group
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

RATIONALE: Interferon alfa may interfere with the growth of cancer cells. PURPOSE: Phase II trial to study the effectiveness of interferon alfa in treating children with an HIV-related cancer including leukemia, non-Hodgkin's lymphoma, CNS lymphoma, or other solid tumors.

Eligible Conditions
  • Lymphoma
  • Leukemia
  • Solid Tumors

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2008 Phase 2 trial • 26 Patients • NCT00003656
92%
Xeroderma - Grade 1
75%
Anorexia - Grade 1
67%
Neurologic - Grade 1
67%
Altered Mood - Grade 1
58%
Fatigue - Grade 1
42%
Fatigue - Grade 2
42%
Constipation - Grade 1
42%
Diarrhea - Grade 1
33%
Cough - Grade 1
33%
Fever - Grade 1
25%
Anemia - Grade 1
25%
Neurologic - Grade 2
17%
Anemia - Grade 3
17%
Cough - Grade 2
17%
Nausea/Vomiting - Grade 1
17%
Nausea/Vomiting - Grade 2
17%
Anorexia - Grade 2
17%
Leukopenia - Grade 1
17%
Leukopenia - Grade 2
17%
Leukopenia - Grade 3
17%
Thrombocytopenia - Grade 1
8%
Leukopenia
8%
Neurologic - Grade 3
8%
Skin - Grade 1
8%
Fever - Grade 2
8%
Renal - Grade 2
8%
Renal - Grade 1
8%
Anemia - Grade 2
8%
Liver - Grade 1
100%
80%
60%
40%
20%
0%
Study treatment Arm
Phase 1 Group
Phase 2 Group

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Alpha interferon (aIFN) treatmentExperimental Treatment1 Intervention
See detailed description.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Benzalkonium
FDA approved

Find a Location

Who is running the clinical trial?

Children's Oncology GroupLead Sponsor
460 Previous Clinical Trials
240,029 Total Patients Enrolled
62 Trials studying Lymphoma
24,009 Patients Enrolled for Lymphoma
National Cancer Institute (NCI)NIH
13,920 Previous Clinical Trials
41,017,165 Total Patients Enrolled
1,407 Trials studying Lymphoma
383,417 Patients Enrolled for Lymphoma
V. M. Whitehead, MDStudy ChairMontreal Children's Hospital at McGill University Health Center
~0 spots leftby Nov 2025
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