A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
Recruiting in Palo Alto (17 mi)
+47 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Genentech, Inc.
No Placebo Group
Prior Safety Data
Trial Summary
What is the purpose of this trial?
This Phase II, multicenter, randomized trial is designed to make preliminary evaluations of the efficacy of combining bevacizumab with chemotherapy (docetaxel or pemetrexed) or Tarceva relative to chemotherapy (docetaxel or pemetrexed) alone in patients with previously treated advanced NSCLC.
Eligibility Criteria
Inclusion Criteria
Signed written informed consent
Histologically or cytologically proven Stage IIIb with pleural effusion, or Stage IV, recurrent non-squamous NSCLC that is recurrent and unresectable
Progression after one line of platinum-based chemotherapy (patients who have received prior docetaxel treatment are eligible to participate if there are no contraindications for pemetrexed treatment)
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Treatment Details
Interventions
- Bevacizumab (Monoclonal Antibodies)
- Docetaxel (Taxanes)
- Pemetrexed (Anti-metabolites)
- Tarceva (Tyrosine Kinase Inhibitor)
Bevacizumab is already approved in European Union, United States, Japan, Canada for the following indications:
🇪🇺 Approved in European Union as Avastin for:
- Colorectal cancer
- Breast cancer
- Non-small cell lung cancer
- Renal cell carcinoma
- Ovarian cancer
🇺🇸 Approved in United States as Avastin for:
- Colorectal cancer
- Non-small cell lung cancer
- Glioblastoma
- Renal cell carcinoma
- Cervical cancer
- Ovarian cancer
🇯🇵 Approved in Japan as Avastin for:
- Colorectal cancer
- Non-small cell lung cancer
- Breast cancer
- Renal cell carcinoma
- Ovarian cancer
🇨🇦 Approved in Canada as Avastin for:
- Colorectal cancer
- Non-small cell lung cancer
- Breast cancer
- Renal cell carcinoma
- Ovarian cancer
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Sansum Santa Barbara Medical Foundation Clinic (TORI)Santa Barbara, CA
Santa Barbara Hematology Oncology Medical Group, Inc (TORI)Santa Barbara, CA
The Florida Cancer Institute(TORI)Orlando, FL
Comprehensive Cancer Centers of Nevada (TORI)Las Vegas, NV
More Trial Locations
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Who Is Running the Clinical Trial?
Genentech, Inc.Lead Sponsor