Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors
Recruiting in Palo Alto (17 mi)
+12 other locations
Age: < 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Children's Oncology Group
No Placebo Group
Prior Safety Data
Trial Summary
What is the purpose of this trial?
RATIONALE: Radiation therapy uses x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of radiation therapy and chemotherapy and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of radiation therapy, chemotherapy and peripheral stem cell transplantation in treating patients with primitive neuroectodermal tumors.
Eligibility Criteria
Inclusion Criteria
Atypical teratoid/rhabdoid tumor Medulloblastoma
Desmoplastic medulloblastoma
Ependymoblastoma
See 7 more
Treatment Details
Interventions
- Bone Marrow Ablation with Stem Cell Support (Bone Marrow Ablation)
- Carboplatin (Platinum-containing Compound)
- Cyclophosphamide (Alkylating agents)
- Filgrastim (Hematopoietic Growth Factor)
- Peripheral Blood Stem Cell Transplantation (Stem Cell Transplantation)
- Radiation Therapy (Radiation Therapy)
- Thiotepa (Other)
- Vincristine Sulfate (Vinca alkaloids)
Participant Groups
1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment8 Interventions
See detailed description.
Carboplatin is already approved in United States, European Union, Canada for the following indications:
🇺🇸 Approved in United States as Paraplatin for:
- Ovarian cancer
- Testicular cancer
- Lung cancer
- Head and neck cancer
- Brain cancer
🇪🇺 Approved in European Union as Carboplatin for:
- Ovarian cancer
- Small cell lung cancer
🇨🇦 Approved in Canada as Carboplatin for:
- Ovarian cancer
- Small cell lung cancer
- Testicular cancer
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Memorial Sloan-Kettering Cancer CenterNew York, NY
Children's Hospital Medical Center - CincinnatiCincinnati, OH
NYU School of Medicine's Kaplan Comprehensive Cancer CenterNew York, NY
Children's Hospital of ColumbusColumbus, OH
More Trial Locations
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Who Is Running the Clinical Trial?
Children's Oncology GroupLead Sponsor
National Cancer Institute (NCI)Collaborator