~24 spots leftby Jan 2026

Individualized Obesity Pharmacotherapy

Palo Alto (17 mi)
Overseen byAndres J Acosta
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 3
Waitlist Available
Sponsor: Mayo Clinic
No Placebo Group
Pivotal Trial (Near Approval)
Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing if choosing weight loss medications based on individual body traits works better than picking them randomly. Participants with obesity will either get a medication chosen for them or one picked without considering their traits. The study will track their progress to see which method is more effective.

Eligibility Criteria

Treatment Details

2Treatment groups
Experimental Treatment
Active Control
Group I: Intervention groupExperimental Treatment3 Interventions
Phenotype-guided pharmacotherapy, which includes Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion or Phentermine plus Exercise
Group II: Control GroupActive Control4 Interventions
Randomly assigned pharmacotherapy, which includes Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion or Phentermine
Liraglutide is already approved in United States, United States, European Union, European Union for the following indications:
πŸ‡ΊπŸ‡Έ Approved in United States as Victoza for:
  • Type 2 diabetes mellitus treatment
  • Cardiovascular risk reduction in adults with type 2 diabetes and heart disease
πŸ‡ΊπŸ‡Έ Approved in United States as Saxenda for:
  • Weight loss treatment in adults and children aged 12 and older with obesity
πŸ‡ͺπŸ‡Ί Approved in European Union as Victoza for:
  • Type 2 diabetes mellitus treatment
  • Cardiovascular risk reduction in adults with type 2 diabetes and heart disease
πŸ‡ͺπŸ‡Ί Approved in European Union as Saxenda for:
  • Weight loss treatment in adults and children aged 12 and older with obesity

Find a clinic near you

Research locations nearbySelect from list below to view details:
Mayo Clinic in RochesterRochester, MN
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Who is running the clinical trial?

Mayo ClinicLead Sponsor

References