← Back to Search

Huo-Luo-Xiao-Ling for Osteoarthritis (TCM-OAK Trial)

Phase 2
Waitlist Available
Led By Brian M. Berman, MD
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Summary

The purpose of this study is to determine if the traditional Chinese herbal compound (Huo-Luo-Xiao-Ling Dan, or HLXL) is effective in treating OA of the knee in addition to participants current OA of the knee treatment(s) and also to determine the best dosage of HLXL that is safe and well tolerated.

Eligible Conditions
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
‡Pain Normalized Score
Secondary study objectives
Function Normalized Score
Patient Global Assessment

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Huo-Luo-Xiao-LingActive Control1 Intervention
Active herb Huo-Luo-Xiao-Ling (HLXL) The subjects in the HLXL group received the medium dose of HLXL (10 capsules/day or 4,000mg/day) in the first 2 weeks to evaluate safety. If no adverse effects were observed, the dose was increased to 14 capsules per day (5,600 mg/day) for the subsequent 6 weeks.
Group II: PlaceboPlacebo Group1 Intervention
Placebo Huo-Luo-Xiao-Ling (HLXL): Subjects in the placebo group received an equal number of placebo capsule.

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor
705 Previous Clinical Trials
378,322 Total Patients Enrolled
3 Trials studying Osteoarthritis
56 Patients Enrolled for Osteoarthritis
National Center for Complementary and Integrative Health (NCCIH)NIH
848 Previous Clinical Trials
672,824 Total Patients Enrolled
23 Trials studying Osteoarthritis
5,742 Patients Enrolled for Osteoarthritis
Brian M. Berman, MDPrincipal InvestigatorUniversity of Maryland, Baltimore
~5 spots leftby Sep 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top