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Ropivacaine Continuous Infusion for Osteoarthritis

Phase 3
Waitlist Available
Led By Benjamin Wilke, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 days, or until discontinuation of narcotic medication (whichever is later)
Awards & highlights

Study Summary

This trial will study how well a pain-relieving catheter works for people who have had knee-replacement surgery. The catheter will give either a large dose of medication all at once or a small continuous infusion of pain medicine.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 days, or until discontinuation of narcotic medication (whichever is later)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 days, or until discontinuation of narcotic medication (whichever is later) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Post-operative Pain Levels
Secondary outcome measures
Amount of Medication Administered
Duration of Narcotic Used

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Ropivacaine intermittent bolusExperimental Treatment1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in pulsed intermittent bolus.
Group II: Ropivacaine continuousExperimental Treatment1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in a continuous infusion.
Group III: Single shot adductor canalPlacebo Group1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with saline.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ropivacaine Intermittent Bolus
2022
Completed Phase 3
~60
Ropivacaine Continuous Infusion
2022
Completed Phase 3
~60

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,242 Previous Clinical Trials
3,773,689 Total Patients Enrolled
29 Trials studying Osteoarthritis
2,850 Patients Enrolled for Osteoarthritis
Benjamin Wilke, MDPrincipal InvestigatorMayo Clinic
2 Previous Clinical Trials
145 Total Patients Enrolled
~19 spots leftby Jun 2025
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