A Study of Cabiralizumab Given With Nivolumab With and Without Chemotherapy in Patients With Advanced Pancreatic Cancer
Recruiting in Palo Alto (17 mi)
+73 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Bristol-Myers Squibb
No Placebo Group
Prior Safety Data
Breakthrough Therapy
Trial Summary
What is the purpose of this trial?
The purpose of this study is to determine whether an investigational immuno-therapy, cabiralizumab in combination with nivolumab, with or without chemotherapy, is effective for the treatment of advanced pancreatic cancer.
Eligibility Criteria
Inclusion Criteria
ECOG Performance status 0-1
Your organs are working properly.
Measurable disease
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Exclusion Criteria
You have heart problems that are not currently managed or are severe.
You have tumors that have spread to your brain or spinal cord.
You have received certain types of immune cell-modulating medications in the past.
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Treatment Details
Interventions
- Cabiralizumab (Monoclonal Antibodies)
- Fluorouracil (Chemotherapy)
- Gemcitabine (Chemotherapy)
- Irinotecan Hydrochloride (Chemotherapy)
- Leucovorin (Chemotherapy)
- Nab-paclitaxel (Chemotherapy)
- Nivolumab (Checkpoint Inhibitor)
- Oxaliplatin (Chemotherapy)
Participant Groups
4Treatment groups
Experimental Treatment
Active Control
Group I: Arm DExperimental Treatment5 Interventions
Cabiralizumab Q2W + Nivolumab Q4W and Oxaliplatin/5-Flurouracil/Leucovorin (FOLFOX) Q2W
Group II: Arm CExperimental Treatment4 Interventions
Cabiralizumab Q2W + Nivolumab Q4W and Gemcitabine + Nab-Paclitaxel (Abraxane®) D1, 8 and 15 Q4W
Group III: Arm BExperimental Treatment2 Interventions
Cabiralizumab Q2W + Nivolumab Q4W
Group IV: Arm AActive Control6 Interventions
Investigator choice of chemotherapy:
Gemcitabine/Nab-Paclitaxel (Abraxane®) or 5-Fluorouracil/Leucovorin/Irinotecan Liposome (ONIVYDE)
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Mayo Clinic in Rochester, MinnesotaPhoenix, AZ
HonorHealth Research InstituteScottsdale, AZ
Local Institution - 0001Baltimore, MD
Dana Farber Cancer Institute.Boston, MA
More Trial Locations
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Who Is Running the Clinical Trial?
Bristol-Myers SquibbLead Sponsor