A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer
(CARRIE Trial)
Recruiting in Palo Alto (17 mi)
+64 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Merrimack Pharmaceuticals
No Placebo Group
Prior Safety Data
Trial Summary
What is the purpose of this trial?
The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients with high serum levels of free IGF-1.
Eligibility Criteria
Inclusion Criteria
Metastatic adenocarcinoma of the pancreas. Patients with islet cell neoplasms are not eligible.
Patient must have received no prior radiotherapy, surgery, chemotherapy, or investigational therapy for the treatment of metastatic disease.
Blood sample sent for free IGF-1 testing
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Treatment Details
Interventions
- Gemcitabine (Chemotherapy)
- MM-141 (Monoclonal Antibodies)
- Nab-Paclitaxel (Chemotherapy)
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Group I: Arm A (Experimental Arm)Experimental Treatment3 Interventions
MM-141 in combination with nab-paclitaxel and gemcitabine
Group II: Arm B (Comparator Arm)Active Control3 Interventions
Placebo in combination with nab-paclitaxel and gemcitabine
Group III: Observational GroupActive Control1 Intervention
Gemcitabine is already approved in European Union, United States, Canada, Japan for the following indications:
🇪🇺 Approved in European Union as Gemzar for:
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
🇺🇸 Approved in United States as Gemzar for:
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
🇨🇦 Approved in Canada as Gemzar for:
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
🇯🇵 Approved in Japan as Gemzar for:
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Columbia University Medical CenterNew York, NY
Fox Chase Cancer CenterPhiladelphia, PA
Texas Oncology-ParisParis, TX
UCLA School of MedicineLos Angeles, CA
More Trial Locations
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Who Is Running the Clinical Trial?
Merrimack PharmaceuticalsLead Sponsor