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Monoclonal Antibodies

Mavrilimumab for COVID-19

Phase 2
Waitlist Available
Led By Kristin Hudock, MD
Research Sponsored by Kristin Hudock
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights

Study Summary

This study is evaluating whether a drug may help prevent progression of respiratory failure in individuals with severe pneumonia.

Eligible Conditions
  • COVID-19
  • Pneumonia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Measure
Secondary outcome measures
Measures

Side effects data

From 2021 Phase 2 trial • 40 Patients • NCT04399980
21%
Acute Respiratory Syndrome
16%
Acute Kidney Injury
16%
Hypoxia - Worsening
11%
Acute Respiratory Distress Syndrome
11%
Arrhythmia
11%
Pneumonia
11%
anemia
5%
Elevated Ferritin
5%
Elevated CRP
5%
Pulmonary Embolism
5%
Chronic Respiratory Failure
5%
Fever
5%
Elevated WBC
5%
Clot
5%
Delirium
5%
Hypotension
5%
Headache
5%
Worsening D Dimer
5%
Shock
100%
80%
60%
40%
20%
0%
Study treatment Arm
Control
Intervention

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MavrilimumabExperimental Treatment1 Intervention
Mavrilimumab treatment infusion
Group II: PlaceboPlacebo Group1 Intervention
Placebo infusion
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mavrilimumab
Not yet FDA approved

Find a Location

Who is running the clinical trial?

Kristin HudockLead Sponsor
Kiniksa Pharmaceuticals, Ltd.Industry Sponsor
8 Previous Clinical Trials
1,372 Total Patients Enrolled
3 Trials studying COVID-19
857 Patients Enrolled for COVID-19
Kristin Hudock, MDPrincipal Investigator - University of Cincinnati
University of Cincinnati Medical Center
Georgetown University School Of Medicine (Medical School)
Georgetown University Medical Center (Residency)
~12 spots leftby Jun 2025
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