PSMA-PET/MRI for Prostate Cancer

Recruiting in Palo Alto (17 mi)

Overseen byMichael Repka, MD

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: UNC Lineberger Comprehensive Cancer Center

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

The goal of this study is to investigate the feasibility and toxicity of using prostate-specific membrane antigen-positron emission tomography (PSMA-PET) and multi-parametric magnetic resonance imagining (mpMRI) with PET-MR technology to define radiotherapy targets, while meeting all the current planning criteria.

Eligibility Criteria

This trial is for English-speaking men with prostate adenocarcinoma that's considered intermediate or high-risk. They must have confirmed diagnosis, be able to perform daily activities (ECOG status 0-2), and agree to release personal health information. It's not suitable for those who don't meet these criteria.

Inclusion Criteria

Written informed consent obtained to participate in the study and HIPAA authorization for release of personal health information

My cancer is at an intermediate or high-risk level according to NCCN guidelines.

Subject is willing and able to comply with the protocol as determined by the Treating Investigator

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Exclusion Criteria

Contraindications for MRI

I have no other cancers except for non-melanoma skin cancer or any cancer I've been free of for 5+ years.

I have been diagnosed with inflammatory bowel disease.

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Treatment Details

Interventions

68Ga-HBED-CC-PSMA (Radioisotope)

Trial OverviewThe study tests if using PSMA-PET/MRI technology can help define radiotherapy targets in prostate cancer treatment without increasing toxicity, while still meeting current planning standards.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: PMSA-PET/MRIExperimental Treatment1 Intervention

Patients scheduled to receive PMSA-PET/MRI scan in addition to standard of care CT scan prior to treatment