~28 spots leftby Apr 2026

Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue Sarcoma

(PICASSO III Trial)

Recruiting in Palo Alto (17 mi)
+161 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 3
Waitlist Available
Sponsor: Ziopharm
No Placebo Group
Pivotal Trial (Near Approval)
Prior Safety Data

Trial Summary

What is the purpose of this trial?

This is an international, randomized, double-blind, placebo-controlled trial to evaluate the clinical efficacy of palifosfamide-tris administered with doxorubicin in combination, compared with doxorubicin administered with placebo in front-line patients diagnosed with metastatic soft tissue sarcoma (STS).

Research Team

Eligibility Criteria

Inclusion Criteria

Age ≥18 years.
Documented soft tissue sarcoma
Metastatic disease for which the patient has not received any prior treatment, and for whom treatment with doxorubicin is considered medically acceptable.
See 7 more

Treatment Details

Interventions

  • Doxorubicin (Alkylating agents)
  • Palifosfamide-tris (Alkylating agents)
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: doxorubicin plus palifosfamide-trisExperimental Treatment1 Intervention
Group II: doxorubicin plus placeboActive Control1 Intervention

Doxorubicin is already approved in Canada, Japan for the following indications:

🇨🇦
Approved in Canada as Doxorubicin for:
  • Breast cancer
  • Ovarian cancer
  • Bladder cancer
  • Lymphomas
  • Leukemias
  • Multiple myeloma
  • Kaposi's sarcoma
  • Soft tissue sarcomas
🇯🇵
Approved in Japan as Doxorubicin for:
  • Breast cancer
  • Ovarian cancer
  • Bladder cancer
  • Lymphomas
  • Leukemias
  • Multiple myeloma
  • Kaposi's sarcoma
  • Soft tissue sarcomas

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
NCT01168791Orlando, FL
Moffitt Cancer CenterTampa, FL
University of Colorado Cancer CenterAurora, CO
Summa Health SystemAkron, OH
More Trial Locations
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Who Is Running the Clinical Trial?

Ziopharm

Lead Sponsor

Trials
36
Patients Recruited
4,000+

Alaunos Therapeutics

Lead Sponsor

Trials
41
Patients Recruited
4,200+