← Back to Search

Other

LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)

Phase 2
Waitlist Available
Research Sponsored by Lyra Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through week 28

Summary

This trial is testing a new treatment called LYR-220 for adults with chronic sinus problems who have already had surgery. The study will check if the treatment is safe, how well it works, and how the body processes it. LYR-220 is a novel drug delivery system designed to provide long-term topical steroid therapy for chronic rhinosinusitis.

Eligible Conditions
  • Chronic Sinusitis
  • Sinusitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through week 28
This trial's timeline: 3 weeks for screening, Varies for treatment, and through week 28 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Plasma MF concentrations
Product-related unexpected serious adverse events
Secondary study objectives
Adverse Events
Change in Chronic Rhinosinusitis (CRS) symptom scores
Endoscopic findings
+4 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment Arm B: LYR-220 Design 2Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 2
Group II: Treatment Arm A: LYR-220 Design 1Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 1
Group III: Treatment Arm C: Bilateral sham procedure controlPlacebo Group1 Intervention
Bilateral sham procedure control
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LYR-220 Design 2
2021
Completed Phase 2
~50
LYR-220 Design 1
2021
Completed Phase 2
~50

Find a Location

Who is running the clinical trial?

Lyra TherapeuticsLead Sponsor
4 Previous Clinical Trials
469 Total Patients Enrolled
3 Trials studying Chronic Sinusitis
287 Patients Enrolled for Chronic Sinusitis
~12 spots leftby Dec 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top