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Blood Pressure Management in Stroke Following Endovascular Treatment (DETECT Trial)

Phase 2

Waitlist Available

Led By Aristeidis H Katsanos, MD

Research Sponsored by Hamilton Health Sciences Corporation

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 18 months

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient outcomes.

Eligible Conditions

Stroke
Mechanical Thrombectomy
Endovascular Thrombectomy
Vascular Occlusion
High Blood Pressure

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 18 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 18 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 18 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Mean enrollment rate.

Number of participants with treatment allocation change.

Secondary study objectives

Absolute difference in flow velocity measurements in transcranial Doppler.

Absolute difference in the NIH Stroke Scale change at day 1.

Absolute difference in the NIH Stroke Scale change at day 2.

+1 more

Other study objectives

Absolute difference in final infarct volumes.

Absolute difference in hospital stay.

Absolute difference in mean systolic blood pressure values.

+9 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intensive Blood Pressure managementExperimental Treatment3 Interventions

Participants assigned to the intensive blood pressure management arm will be treated using approved antihypertensive medications to have systolic blood pressure readings under 140 mmHg for the first 48 hours after enrollment into the study.

Group II: Standard Blood Pressure managementActive Control3 Interventions

Participants assigned to the standard blood pressure management arm will be treated using approved antihypertensive medications to have systolic blood pressure readings under 180 mmHg for the first 48 hours after enrollment into the study.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Enalapril

2016

Completed Phase 4

~13690

Labetalol

2020

Completed Phase 4

~2490