Trial Summary
What is the purpose of this trial?This is a 3-arm single center study of 45 patients. These cohorts will include 15 breast patients scheduled to undergo a biopsy, and 15 thyroid patients scheduled to undergo fine needle aspiration, biopsy, or thyroidectomy that consent to undergo an acoustic angiography in conjunction with b-mode ultrasound prior to their scheduled biopsy. Prior to imaging clinical patients, the third arm will include 15 healthy volunteers that will be imaged to optimize imaging parameters.
Eligibility Criteria
This trial is for adults who can consent and are scheduled for certain breast or thyroid biopsies or surgeries at UNC. Women must not be pregnant. Excluded are those in critical condition, with severe heart issues, known allergies to Definity®, men, and anyone with larger or deeper lesions than specified.Inclusion Criteria
You have a mammogram result with a score of 4 or 5.
The patient had a breast ultrasound study done at UNC.
The patient received a thyroid ultrasound study at UNC.
+5 more
Exclusion Criteria
I am not critically ill or medically unstable.
I do not have severe heart problems like recent heart attacks or unstable angina.
My breast lump is larger than 2cm or deeper than 3cm from the skin.
+3 more
Participant Groups
The study tests a new ultrasound technique called Acoustic Angiography combined with standard imaging on patients with breast or thyroid conditions before their biopsies/surgeries. It also includes healthy volunteers to fine-tune the imaging process.
3Treatment groups
Experimental Treatment
Group I: Thyroid Imaging CohortExperimental Treatment2 Interventions
A total of 15 participants with known thyroid lesions that are already scheduled to undergo a clinical biopsy
Group II: Healthy Volunteers CohortExperimental Treatment2 Interventions
A total of 15 participants will be included to optimize imaging parameters.
Group III: Breast Imaging CohortExperimental Treatment2 Interventions
A total of 15 women with known breast lesions that are already scheduled to undergo a clinical biopsy
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Univeristy of North Carolina Chapel HillChapel Hill, NC
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Who Is Running the Clinical Trial?
UNC Lineberger Comprehensive Cancer CenterLead Sponsor
National Cancer Institute (NCI)Collaborator