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A for Tonsillitis

Phase 2
Waitlist Available
Led By Douglas VanDaele, MD
Research Sponsored by University of Iowa
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day of procedure through post-operative day 10
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions

Summary

The hypothesis is that celecoxib effectively reduces pain after a tonsillectomy and reduces post-operative narcotic use. To test this hypothesis, the study is placebo controlled (sugar pill). Half of the participants will receive a sugar pill, half will not. All participants will receive the standard post-operative pain medications. We ask participants to log the amount of medications they use daily, and the amount of pain they have each day. It is hoped that celecoxib will reduce the amount of post-operative pain medication needed.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day of procedure through post-operative day 10
This trial's timeline: 3 weeks for screening, Varies for treatment, and day of procedure through post-operative day 10 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Self-reported Pain Score
Secondary study objectives
Acetaminophen Equivalent Use
Incidence of Post-operative Hemorrhage
Self-reported Activity Level
+1 more

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: AActive Control1 Intervention
Celecoxib 200 mg tablets
Group II: BPlacebo Group1 Intervention
Placebo with same dosing schedule as the active comparator arm

Find a Location

Who is running the clinical trial?

University of IowaLead Sponsor
463 Previous Clinical Trials
893,244 Total Patients Enrolled
PfizerIndustry Sponsor
4,645 Previous Clinical Trials
17,743,142 Total Patients Enrolled
5 Trials studying Tonsillitis
1,758 Patients Enrolled for Tonsillitis
Douglas VanDaele, MDPrincipal InvestigatorDepartment of Otolaryngology-Head & Neck Surgery
~1 spots leftby Oct 2025
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