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Nicotinic Acetylcholine Receptor Antagonist

0.5 mg dexmecamylamine (TC-5214) for Overactive Bladder

Phase 2
Waitlist Available
Research Sponsored by Targacept Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

Overactive bladder (OAB) is a syndrome characterized by symptoms of a sudden need to urinate with or without incontinence (leaking). The purpose of this study is to test whether dexmecamylamine is safe and effective compared to placebo for the treatment of symptoms of OAB.

Eligible Conditions
  • Overactive Bladder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in micturition frequency per 24 hours
Secondary outcome measures
Change from baseline in nocturia per 24 hours

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: 2 mg dexmecamylamine (TC-5214)Experimental Treatment1 Intervention
One tablet of 2 mg dexmecamylamine to be administered orally twice a day.
Group II: 1 mg dexmecamylamine (TC-5214)Experimental Treatment1 Intervention
One tablet of 1 mg dexmecamylamine to be administered orally twice a day.
Group III: 0.5 mg dexmecamylamine (TC-5214)Experimental Treatment1 Intervention
One tablet of 0.5 mg dexmecamylamine to be administered orally twice a day.
Group IV: PlaceboPlacebo Group1 Intervention
One tablet of placebo to be administered orally twice a day.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexmecamylamine
Not yet FDA approved

Find a Location

Who is running the clinical trial?

Targacept Inc.Lead Sponsor
21 Previous Clinical Trials
8,169 Total Patients Enrolled
~133 spots leftby Sep 2025
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