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General Anesthetic

Sevoflurane Versus Propofol on Optic Nerve Sheath Diameter During Anesthesia in Steep Trendelenburg Position

Phase 4
Waitlist Available
Research Sponsored by State University of New York - Downstate Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All patients scheduled to undergo surgery in the steep Trendelenburg position at SUNY Downstate Medical Center.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
Approved for 10 Other Conditions
All Individual Drugs Already Approved
Pivotal Trial
Drug Has Already Been Approved
No Placebo-Only Group

Summary

This trial will compare the change in optic nerve sheath diameter during anesthesia with sevoflurane or propofol in patients undergoing urologic or gynecologic surgery in the Trendelenburg position.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Sevoflurane Versus Propofol on Optic Nerve Sheath Diameter During Anesthesia in Steep Trendelenburg Position

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Group BExperimental Treatment1 Intervention
Group B will begin anesthesia with propofol-only then will be switched to sevoflurane-only.
Group II: Group AExperimental Treatment1 Intervention
Group A will begin anesthesia maintenance with sevoflurane-only, then will be switched after 30 minutes to anesthesia with propofol-only.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propofol
FDA approved

Find a Location

Who is running the clinical trial?

State University of New York - Downstate Medical CenterLead Sponsor
66 Previous Clinical Trials
12,117 Total Patients Enrolled
~7 spots leftby Dec 2025
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