Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
Trial Summary
What is the purpose of this trial?
After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy. Now there is a recent literature suggesting a single-drug therapy may be safe and adequate. In fact, using zosyn (piperacillin-tazobactam) as a single-drug therapy, there are additional benefits of simplicity, compliance, and lower infectious complications. Currently surgeons are already using both 2-drug regimen (ceftriaxone/metronidazole) and single-drug regimen (zosyn) interchangeable as both are FDA approved and regulated antibiotics for intra-abdominal infection. There is a clear need to compare outcomes between these two options.
Research Team
Justin Lee, MD
Principal Investigator
Phoenix Childrens Hospital
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- Piperacillin (Anti-tumor antibiotic)
- Tazobactam (Beta-lactamase inhibitor)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Phoenix Children's Hospital
Lead Sponsor