← Back to Search

Antidepressant

Bupropion XL for Depression

Phase 4
Waitlist Available
Led By Andrew Miller, MD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 2, week 4, week 6, week 8
Awards & highlights

Study Summary

This trial will test whether bupropion can help people with depression and increased inflammation who also have problems with anhedonia.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 2, week 4, week 6, week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 2, week 4, week 6, week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Targeted Ventromedial Prefrontal Cortex-Ventral Striatal (vmPFC-VS) Functional Connectivity (FC)
Secondary outcome measures
Inventory of Depressive Symptomatology - Self-Report (IDS-SR)
Motivation and Pleasure Scale-Self-Report (MAP-SR) Score
Proportion of Hard-Task Choices During the Effort-Expenditure for Rewards Task (EEfRT)
+1 more

Side effects data

From 2022 Phase 4 trial • 18 Patients • NCT04352101
20%
Itching
20%
Nausea
20%
Anxious mood
10%
Insomnia
10%
Dry mouth
10%
Vivid dreams
10%
Pain in limb
10%
Nocturnal perspiration
10%
Lightheadedness
10%
Headache
10%
Stress
10%
Chest pain
10%
High blood pressure
10%
Enlarged lymph nodes
100%
80%
60%
40%
20%
0%
Study treatment Arm
Bupropion
Escitalopram

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: BupropionExperimental Treatment1 Intervention
Participants randomized to take bupropion for 8 weeks.
Group II: EscitalopramActive Control1 Intervention
Participants randomized to take escitalopram for 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupropion XL
2009
Completed Phase 4
~370

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,646 Previous Clinical Trials
2,564,582 Total Patients Enrolled
59 Trials studying Depression
8,998 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,798 Previous Clinical Trials
2,660,900 Total Patients Enrolled
672 Trials studying Depression
253,325 Patients Enrolled for Depression
Andrew Miller, MDPrincipal InvestigatorEmory University
2 Previous Clinical Trials
374 Total Patients Enrolled
1 Trials studying Depression
20 Patients Enrolled for Depression
~4 spots leftby Jun 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top